Introduction
Gelpol
Carbomers are manufactured by two different routes – (1) Benzene route (2) Benzene-free route (preferred). Specifically, the “traditional” polymers are synthesized in benzene and the “toxicologically preferred”, polymers are synthesized in either ethyl acetate or a cosolvent mixture of ethyl acetate and cyclohexane.
| In Benzene route there are grades like ;
Gelpol™ 934 Gelpol™ 934P Gelpol™ 940 Gelpol™ 941 Gelpol™ 1342 Benzene-free grades are divided in three parts; Gelpol™ Homopolymers : These are polymers of acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol. Gelpol™ Copolymers : These are polymers of acrylic acid and (C10-C30) alkyl acrylate crosslinked with allyl pentaerythritol. Gelpol™ Interpolymers : These are carbomer homopolymers or copolymers which contain a block copolymer of polyethylene glycol and a long chain alkyl acid ester. |
 |
| Grades : | Type A | Type B | Type C |
|---|---|---|---|
| Gelpol™ Homopolymers | 71 G, 971P, 981 (4,000-11,000 cP) |
974P (25,000-45,000 cP) |
980 (40,000-60,000 cP) |
| Gelpol™ Copolymers | TR 2 (4,500-13,500 cP) |
TR 1 (10,000-29,000 cP) |
– |
| Gelpol™ Interpolymers | U-10, U-20 (45,000-60,000 cP) |
EZE 2020 (47,000-77,000 cP) |
– |
However it may be preferable to substitute a benzene routed corbomer with a non-benzene routed carbomer in a pharmaceutical formulation due to regulatory restrictions on the use of benzene in pharmaceutical formulation. Hence, KBH Polymers Pvt. Ltd. recommends that carbomers polymerized in either ethyl acetate or a cosolvent mixture of ethyl acetate and cyclohexane to be used for new drug development projects.
Polycarbophil for bioadhesive application/laxative tablet application
- Gelpol™ AA-1 : Polycarbophil Bioadhesive application
- Gelpol™ CA-1 : Calcium Polycarbophil Laxative tablet application
- Gelpol™ CA-2 : Calcium Polycarbophil Laxative tablet application