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Introduction

Gelpol

Where thickening consistency matters!
Gelpol™ (where thickening consistency matters !) range of products are synthetic high molecular weight, cross-linked acrylic acid based polymers which are water soluble polyacrylic acids and conforms to USP/NF monograph as ‘Carbomers’.

Carbomers are manufactured by two different routes – (1) Benzene route (2) Benzene-free route (preferred). Specifically, the “traditional” polymers are synthesized in benzene and the “toxicologically preferred”, polymers are synthesized in either ethyl acetate or a cosolvent mixture of ethyl acetate and cyclohexane.

In Benzene route there are grades like ;

Gelpol™ 934       Gelpol™ 934P       Gelpol™ 940

Gelpol™ 941       Gelpol™ 1342

Benzene-free grades are divided in three parts;

Gelpol™ Homopolymers : These are polymers of acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol.

Gelpol™ Copolymers : These are polymers of acrylic acid and (C10-C30) alkyl acrylate crosslinked with allyl pentaerythritol.

Gelpol™ Interpolymers : These are carbomer homopolymers or copolymers which contain a block copolymer of polyethylene glycol and a long chain alkyl acid ester.

Gelpol
Grades : Type A Type B Type C
Gelpol™ Homopolymers 71 G, 971P, 981
(4,000-11,000 cP)
974P
(25,000-45,000 cP)
980
(40,000-60,000 cP)
Gelpol™ Copolymers TR 2
(4,500-13,500 cP)
TR 1
(10,000-29,000 cP)
Gelpol™ Interpolymers U-10, U-20
(45,000-60,000 cP)
EZE 2020
(47,000-77,000 cP)

However it may be preferable to substitute a benzene routed corbomer with a non-benzene routed carbomer in a pharmaceutical formulation due to regulatory restrictions on the use of benzene in pharmaceutical formulation. Hence, KBH Polymers Pvt. Ltd. recommends that carbomers polymerized in either ethyl acetate or a cosolvent mixture of ethyl acetate and cyclohexane to be used for new drug development projects.

Polycarbophil for bioadhesive application/laxative tablet application

  • Gelpol™ AA-1 : Polycarbophil Bioadhesive application
  • Gelpol™ CA-1 : Calcium Polycarbophil Laxative tablet application
  • Gelpol™ CA-2 : Calcium Polycarbophil Laxative tablet application
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