Carbomers are manufactured by two different routes – (1) Benzene route (2) Benzene-free route (preferred). Specifically, the “traditional” polymers are synthesized in benzene and the “toxicologically preferred”, polymers are synthesized in either ethyl acetate or a cosolvent mixture of ethyl acetate and cyclohexane.
|In Benzene route there are grades like ;
Gelpol™ 934 Gelpol™ 934P Gelpol™ 940
Gelpol™ 941 Gelpol™ 1342
Benzene-free grades are divided in three parts;
Gelpol™ Homopolymers : These are polymers of acrylic acid crosslinked with allyl sucrose or allyl pentaerythritol.
Gelpol™ Copolymers : These are polymers of acrylic acid and (C10-C30) alkyl acrylate crosslinked with allyl pentaerythritol.
Gelpol™ Interpolymers : These are carbomer homopolymers or copolymers which contain a block copolymer of polyethylene glycol and a long chain alkyl acid ester.
|Grades :||Type A||Type B||Type C|
|Gelpol™ Homopolymers||71 G, 971P, 981
|Gelpol™ Copolymers||TR 2
|Gelpol™ Interpolymers||U-10, U-20
However it may be preferable to substitute a benzene routed corbomer with a non-benzene routed carbomer in a pharmaceutical formulation due to regulatory restrictions on the use of benzene in pharmaceutical formulation. Hence, KBH Polymers Pvt. Ltd. recommends that carbomers polymerized in either ethyl acetate or a cosolvent mixture of ethyl acetate and cyclohexane to be used for new drug development projects.
Polycarbophil for bioadhesive application/laxative tablet application
- Gelpol™ AA-1 : Polycarbophil Bioadhesive application
- Gelpol™ CA-1 : Calcium Polycarbophil Laxative tablet application
- Gelpol™ CA-2 : Calcium Polycarbophil Laxative tablet application